Fire needling stripping after local anesthesia for verruca vulgaris: a multi-center randomized controlled trial / 中国针灸

OBJECTIVE@#To compare the clinical therapeutic effect of fire needling stripping after local anesthesia, simple fire needling and liquid nitrogen cryotherapy on verruca vulgaris.@*METHODS@#A total of 900 patients with verruca vulgaris were randomized into a fire needling stripping group (300 cases, 2 cases dropped off), a fire needling group (300 cases, 4 cases dropped off) and a liquid nitrogen cryotherapy group (300 cases, 5 cases dropped off). After local anesthesia of compound lidocaine cream, fire needling therapy was adopted, and the necrotic tissue of verruca was stripped in the fire needling stripping group. Simple fire needling therapy was adopted in the fire needling group, without local anesthesia and stripping. Liquid nitrogen cryotherapy was adopted in the liquid nitrogen cryotherapy group. The treatment was given once a week, and totally 3 weeks were required in the 3 groups. The skin lesion scores of number, area, thickness, color, pruritus, isomorphism and the level of T lymphocyte (CD@*RESULTS@#Compared before treatment, the skin lesion scores were decreased (@*CONCLUSION@#Fire needling stripping after local anesthesia can effectively treat the verruca vulgaris, improve the skin lesion and immunity, its therapeutic effect is superior to simple fire needling and liquid nitrogen cryotherapy.

Clinical Efficacy of Modified Sanxue Gegentang Combined with Nerve Block on Postherpetic Neuralgia Due to Blood Stasis Syndrome / 中国实验方剂学杂志

Objective:To observe the efficacy of modified Sanxue Gegentang combined with nerve block in treating postherpetic neuralgia due to blood stasis syndrome， and explore its possible mechanism. Method:The 120 patients were randomly divided into control group and observation group， with 60 cases in each group. The patients in control group received Dahuang Zhechong tablet + nerve block， and the patients in observation group received modified Sanxue Gegentang + nerve block for 4 weeks. The clinical symptoms （simplified McGill pain scale， overall impression change scale， traditional Chinese medicine symptoms）， serum medium pain ［endothelin-1 （ET-1）， prostaglandin E2 （PGE2）， substance P （SP）， cydooxygenase-2 （COX-2）］， blood viscosity index ［high blood viscosity （HBV）， medium blood viscosity （MBV）， low blood viscosity （LBV）， and plasma viscosity （PV）］ were observed before and after treatment. The clinical efficacy， recurrence rate in 12 months follow-up， and the incidence of adverse reactions were compared between two groups. Result:The 5 cases in control group and 1 case in the observation group were lost during the study. The total effective rate in observation group was 96.6%（57/59）， higher than 74.5% （41/55） in control group （χ2=5.729， P<0.05）. As compared with control group after treatment， the McGill pain scale， overall impression change rating scale， main TCM symptom scores， pain medium （ET-1， PGE2， SP， COX-2）， and blood viscosity （HBV， MBV， LBV， PV） were significantly lower in observation group （P<0.05）. In the follow-up for 12 months， the recurrence rate was 7.0% （4/57） in observation group， lower than 43.9% （18/41） in control group （χ2=7.294， P<0.05）. During the study period， the incidence of adverse reactions was 8.5% （5/59） in observation group and 7.3% （4/55） in control group， without significant difference between two groups. Conclusion:Modified Sanxue Gegentang combined with nerve block can significantly improve the clinical symptoms of patients with postherpetic neuralgia due to blood stasis syndrome， showing a low recurrence rate incidence of adverse reactions.